"Genes Controlling the Uncrossed Projection of Retinal Ganglion Cells in Pigmented and Albino Mice"

Principal Investigator: Carol Mason, Ph.D., Professor of Pathology and Cell Biology and Neuroscience, College of Physicians and Surgeons, Columbia University

Abstract:

Background: The clinical diagnosis for albinism is an impaired visual response associated with the reduction of optic nerve fibers projecting to targets on the same side of the brain. It has already been determined that the gene, zic2, is required for precise growth of the uncrossed retinal pathway in pigmented mice and that this gene is reduced in the retina of albino mice.

Aim: To identify molecular targets that contribute to the mechanism controlling the distribution of optic nerve fibers at the optic chiasm and that are differently regulated in albino and pigmented mice.

Method:  A combination of molecular and imaging techniques will be used to determine if manipulation of these molecules can restore the uncrossed pathways. An eyecup assay will be created to test and manipulate zic2 expression.

Expected Results: To gain a better understanding of the molecular mechanisms leading to the incorrect distribution of optic nerves in albino mice by identifying additional genes and regulators of this process.

Learn more about Dr. Mason: Dr._Mason_Link.mht (261 KB)